• Functional and structural studies on galectins.
• Development of therapeutic agents based on protein engineering.

• Galectin-9 induces atypical ubiquitination leading to cell death in PC-3 prostate cancer cells.
  Itoh A, et al. Glycobiology 29, 22-35 (2019).
• Small leucine-rich repeat proteoglycans associated with mature insoluble elastin serve as binding sites for galectins.
  Itoh A, et al. Biosci Biotechnol Biochem. 81, 2098-2104 (2017).
• Cooperative interactions of oligosaccharide and peptide moieties of a glycopeptide derived from IgE with galectin-9.
  Nakakita S, et al. J. Biol. Chem. 291, 968-979 (2016).
• Direc cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines.
  Fukata Y, et al. Biochim. Biophys. Acta 1840, 1892-1901 (2014).

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