1. Elucidating the regulatory mechanisms of systemic water conservation.
2. Lessons from aestivation in lungfish ~Biomimetics~.
3. Regulation of body salt in pathophysiological conditions.
4. Elucidating the pathogenesis of water loss-triggered hypertension.
5. Elucidation of the regulatory mechanism of renin-angiotensin-aldosterone system and its involvement in the pathogenesis.
6. Development of cancer therapy targeting the (pro)renin receptor and rare sugar.
7. Elucidation of the involvement of sympathetic nerve activity in the development of hypertension in cardiovascular and renal diseases.
8. Evaluation of the pharmacological properties of novel drugs.
9. Elucidation of the pathology of dolphins and other aquatic organisms and development of diagnostic and therapeutic methods.

• Nishiyama A, et al. Blood pressure adaptation in vertebrates: Comparative biology. Kidney Int. 2022, In-press.
• Marton A, at al. Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation. Nat Rev Nephrol. 2021; 17(1): 65-77.
• Kidoguchi S, et al. New concept of onco-hypertension and future perspectives. Hypertension. 2021; 77(1): 16-27.

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