中村 丈洋

 

経歴:

平成元年3月         法政大学工学部土木工学科卒業

平成7年3月        香川医科大学医学科卒業

平成11年3月       香川医科大学大学院医学研究科修了

平成10年10月       JA香川厚生連 滝宮総合病院医員(脳神経外科)

平成12年3月       香川医科大学医学部附属病院医員(脳神経外科)

平成13年10月       香川医科大学医学部附属病院医員(救命救急センター)

平成14年10月       米国University of Michigan Medical Center研究員

平成16年12月       香川大学医学部研究生

平成17年8月       香川大学医学部附属病院医員(救命救急センター)

平成17年10月       香川大学医学部附属病院院内助手(救命救急センター)

平成18年10月       香川大学医学部助手(脳神経生物学)

平成19年3月        香川大学医学部学内講師(脳神経生物学)

平成19年12月      香川大学医学部講師(脳神経生物学)

 

資格等:

医学博士

日本脳神経外科学会専門医、評議員

日本救急医学会救急科専門医

日本神経外傷学会機関誌編集委員会編集監事

日本脳循環代謝学会評議員

日本生理学会評議員

日本救急医学会認定ICLSコースディレクター

脳卒中初期診療教育コース(ISLS)コースコーディネーター

香川大学医学部附属病院脳死判定資格医

 

研究分野:

頭部外傷および脳卒中に対する低体温療法

頭部外傷および脳卒中後の内在性神経再生

脳出血における病態解明および治療への応用

 

英文論文発表

1. Yang S, Nakamura T, Hua Y, Keep RF, Younger JG, Hoff JT, Xi G. Intracerebral hemorrhage in complement C3-deficient mice. Acta Neurochir (Suppl) 96:227-231, 2006

 

2. Cannon JR, Nakamura T, Keep RF, Richardson RJ, Hua Y, Xi G. Dopamine changes in a rat model of intracerebral hemorrhage. Acta Neurochir (Suppl) 96:222-226, 2006

 

3. Nakamura T, Xi G, Keep RF, Wang M, Nagao S, Hoff JT, Hua Y. Effects of endogenous and exogenous estrogen on intracerebral hemorrhage-induced brain damage in rats. Acta Neurochir (Suppl) 96:218-221, 2006

 

4. Kawai N, Nakamura T, Nagao S. Early hemostatic therapy using recombinant factor VIIa in a collagenase-induced intracerebral hemorrhage model in rats. Acta Neurochir (Suppl) 96:212-217, 2006

 

5. Yang S, Hua Y, Nakamura T, Keep RF, Xi G. Up-regulation of brain ceruloplasmin in thrombin preconditioning. Acta Neurochir (Suppl) 96:203-206, 2006

 

6. Nakamura T, Keep RF, Hua Y, Nagao S, Hoff JT, Xi G. Iron-induced oxidative brain injury after experimental intracerebral hemorrhage. Acta Neurochir (Suppl) 96:194-198, 2006

 

7. Nakamura T, Miyamoto O, Yamashita S, Keep RF, Itano T, Nagao S. Delayed precursor cell marker response in hippocampus following cold injury-induced brain edema. Acta Neurochir (Suppl) 96:134-138, 2006

 

8. Yang S, Nakamura T, Hua Y, Keep RF, Younger JG, He Y, Hoff JT, Xi G. The role of complement C3 in intracerebral hemorrhage-induced brain injury. J Cereb Blood Flow Metab 2006,Epub

 

9. Hua Y, Wu J, Keep RF, Nakamura T, Hoff JT, Xi G.Tumor Necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation. Neurosurgery 58:542-550,2006

 

10. Hua Y, Nakamura T, Keep RF, Wu J, Schallert T, Hoff JT, Xi G. Long-term effects of experimental hemorrhage: the role of iron. J Neurosurg 104:305-312, 2006

 

11. Nakamura T, Kuroda Y, Miyamoto O, Kawai N, Xi G, Keep RF, Tamiya T, Itano T, Nagao S. Iron metabolism after intracerebral hemorrhage in rat brain: role of transferrin. Neurotrauma Research 17:46-49, 2005

 

12. Nakamura T, Keep RF, Hua Y, Park JW, Itano T, Nagao S, Hoff JT, Xi G. Intracerebral hemorrhage induces edema and oxidative stress and alters N-methyl-D-aspartate receptor subunits expression. Acta Neurochir (Suppl) 95:421-424, 2005

 

13. Nakamura T, Hua Y, Keep RF, Park JW, Xi G, Hoff JT. Estrogen therapy for experimental intracerebral hemorrhage in rats. J Neurosurg 103:97-103, 2005

 

14. Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G. Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res 1039:30-36, 2005

 

15. Nakamura T, Xi G, Park JW, Hua Y, Hoff JT, Keep RF. Holo-transferrin and thrombin can interact to cause brain damage. Stroke 36:348-352, 2005

 

16. Yamashita S, Matsumoto Y, Tamiya T, Kawanishi M, Shindo A, Nakamura T, Ogawa D, Kuroda Y, Nagao S. Mechanical thrombolysis for treatment of acute sinus thrombosis--case report. Neurol Med Chir (Tokyo) 45:635-639, 2005

 

17. Yamashita S, Tamiya T, Shindo A, Miyake K, Nakamura T, Ogawa D, Kuroda Y, Nagao S. Improvement of cerebral arterial stenosis associated with Basedow 's disease-case report. Neurol Med Chir (Tokyo) 45:578-582, 2005

 

18. Yamashita S, Kunishio K, Tamiya T, Nakamura T, Ogawa D, Igawa HH, Kuroda Y, Nagao S. Parietal lipomeningocele-case report. Neurol Med Chir (Tokyo) 45:112-115, 2005

 

19. Nakamura T, Miyamoto O, Auer RN, Nagao S, Itano T. Delayed precursor cell markers expression in hippocampus following cold-induced cortical injury in mice. J Neurotrauma 21:1747-1755, 2004

 

20. Nakamura T, Xi G, Hua Y, Schallert T, Hoff JT, Keep RF. Intracerebral hemorrhage in mice: model characterization and application for genetically modified mice. J Cereb Blood Flow Metab 24:487-494, 2004

 

21. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg 100:672-678, 2004

 

22. Kawai N, Nakamura T, Matsumoto Y, Tamiya T_, Nagao: Early hemostatic therapy using recombinant factor VIIa in collagenase-induced_intracerebral hemorrhage in rats. Neurotrauma Research 16, 39-44, 2004                                          

 

23. Nakamura T, Kawai N, Miyamoto O, Xi G, Keep_ RF, Itano T, Hoff JT, Nagao S: Iron-induced oxidative injury after intracerebral hemorrhage in rats. Neurotrauma Research 16, 45-48, 2004

 

24. Wu J, Hua Y, Keep RF, Nakamura T, Hoff JT, Xi G. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 34:2964-2969, 2003

 

25. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G. Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. Neurosurg Focus 15(4):ECP4, 2003

 

26. Nakamura T, Xi G, Hua Y, Hoff JT, Keep RF. Nestin expression after experimental intracerebral hemorrhage. Brain Res 981:108-117, 2003

 

27. Nakamura T, Miyamoto O, Sumitani K, Negi T, Itano T, Nagao S. Do rapid systemic changes of brain temperature have an influence on the brain? Acta Neurochir (Wien) 145:301-307, 2003

 

28. Yamashita S, Miyamoto O, Janjua NA, Tomizawa K, Matsui H, Nakamura T, Nagao S, Itano T. Role of the hippocampal CA2 region following postischemic hypothermia in gerbil. Brain Res Mol Brain Res 111:8-16, 2003

 

29. Nagao S, Irie K, Kawai N, Nakamura T, Kunishio K, Matsumoto Y. The use of mild hypothermia for patients with severe vasospasm: a preliminary report. J Clin Neurosci 10:208-212, 2003

 

30. Kawai N, Nakamura T, Nagao S. Effects of brain hypothermia on brain edema formation after intracerebral hemorrhage in rats. Acta Neurochir (Suppl) 81:233-235, 2002

 

31. Okauchi M, Kawai N, Nakamura T, Kawanishi M, Nagao S. Effects of mild hypothermia and alkalizing agents on brain injuries in rats with acute subdural hematomas. J Neurotrauma 19:741-751, 2002

 

32. Nakamura T, Tatara N, Morisaki K, Kawakita K, Nagao S. Cerebral oxygen metabolism monitoring under hypothermia for severe subarachnoid hemorrhage: report of eight cases. Acta Neurol Scand 106:314-318, 2002

 

33. Kawai N, Nakamura T, Nagao S. Brain hypothermia for ischemic brain damage. No Shinkei Geka 30:1273-1283, 2002

 

34. Nakamura T, Tatara N, Kawai N, Morisaki K, Kawakita K, Ito T, Nagao S. Repeated thalamic haemorrhage: case report and review of the literature. Acta Neurol Scand 104:48-53, 2001

 

35. Nakamura T, Miyamoto O, Kawai N, Negi T, Itano T, Nagao S. Long-term activation of the glutamatergic system associated with N-methyl-D-aspartate receptors after postischemic hypothermia in gerbils. Neurosurgery 49:706-714, 2001

 

36. Nagao S, Irie K, Kawai N, Kunishio K, Ogawa T, Nakamura T, Okauchi M. Protective effect of mild hypothermia on symptomatic vasospasm: a preliminary report. Acta Neurochir (Suppl) 76:547-550, 2000

 

37. Kawai N, Nakamura T, Okauchi M, Nagao S. Effects of hypothermia on intracranial hemodynamics and ischemic brain damage-studies in the rat acute subdural hematoma model. Acta Neurochir (Suppl). 2000;76:529-33, 2000

 

38. Kawai N, Nakamura T, Okauchi M, Nagao S. Effects of hypothermia on intracranial pressure and brain edema formation: studies in a rat acute subdural hematoma model. J Neurotrauma 17:193-202, 2000

 

39. Nagao S, Bemana I, Kuratani H, Takahashi E, Nakamura T. Niravoline, a selective kappa-opioid receptor agonist effectively reduces elevated intracranial pressure. Exp Brain Res 130:338-344, 2000

 

40. Miyamoto O, Sumitani K, Nakamura T, Yamagami S, Miyata S, Itano T, Negi T,  Okabe A: Clostridum perfringens epsilon toxin causes excessive release of glutamate in the mouse hippocampus: FEMS Microbiol Lett 189, 109-113, 2000

 

41. Nakamura T, Miyamoto O, Kawai N, Itano T, Nagao S: Effect of post-ischemic hypothermia and long-term administration of MK801 on neuronal survival in one month after ischemia. Journal of Stroke Cerebrovascular Disease 9 (Suppl 1), 93-94, 2000

 

42. Nakamura T, Tatara N, Morisaki K, Kawakita K, Kawai N, Nagao S: Cerebral oxygen metabolism under hypothermia for severe consciousness disturbance after subarachnoid hemorrhage: Proceedings of the 9th Annual Meeting of the Society for Treatment of Coma, Vol.9, pp51-55, 2000

 

43. Nakamura T, Miyamoto O, Kawai N, Okauchi M, Itano T, Nagao S: Therapeutic window of hypothermia after cold-induced injury in mice. Proceedings of the International Conference on Recent Advances in Neurotraumatology, pp187-191, 1999

 

44. Nakamura T, Miyamoto O, Yamagami S, Fujisawa M, Kawai N, Itano T, Nagao S: The effect of hypothermia on memory function in experimental ischemic model: part 2 -Combined therapy with long-term administration of MK801-: Proceedings of the 8th Annual Meeting of the Society for Treatment of Coma, Vol. 8, pp87-90, 1999

 

45. Nakamura T, Miyamoto O, Yamagami S, Hayashida Y, Itano T, Nagao S. Influence of rewarming conditions after hypothermia in gerbils with transient forebrain ischemia. J Neurosurg 91:114-120, 1999

 

46. Nakamura T, Miyamoto O, Yamagami S, Toyoshima T, Negi T, Itano T, Nagao S. The chronic cell death with DNA fragmentation after post-ischaemic hypothermia in the gerbil hippocampus. Acta Neurochir (Wien) 141:407-413, 1999

 

47. Yamagami S, Miyamoto O, Nakamura T, Okada Y, Negi T, Hayashida Y, Nagao S, Itano T. Suppression of hyperemia after brain ischemia by L-threo-3,4-dihydroxyphenylserine. Neuroreport 9:2939-2943, 1998

 

48. Nakamura T, Nagao S, Kawai N, Honma Y, Kuyama H. Significance of multimodal cerebral monitoring under moderate therapeutic hypothermia for severe head injury. Acta Neurochir (Suppl) 71:85-87, 1998

 

49. Xu RX, Nakamura T, Nagao S, Miyamoto O, Jin L, Toyoshima T, Itano T. Specific inhibition of apoptosis after cold-induced brain injury by moderate postinjury hypothermia. Neurosurgery 43:107-115, 1998

 

50. Miyamoto O, Minami J, Toyoshima T, Nakamura T, Masada T, Nagao S, Negi T, Itano T, Okabe A. Neurotoxicity of Clostridium perfringens epsilon-toxin for the rat hippocampus via the glutamatergic system. Infect Immun 66:2501-2508, 1998

 

51. Kawai N, Nakamura T, Okauchi M, Nagao S: Effects of hypothermia on intracranial hemodynamics and ischemic brain damage _in experimental acute subdural hematoma in the rat. Advances in Neurotrauma Research 10, 13-16, 1998

 

52. Nakamura T, Miyamoto O, Yamagami S, Sumitani K, Kawai N, Negi T, Itano T, Nagao S: The effects of hypothermia after cold-induced injury on neuronal damage in mice. Advances in Neurotrauma Research 10, 23-26, 1998

 

53. Nakamura T, Miyamoto O, Kawai N, Itano T, Nagao S: The effect of hypothermia on memory function in experimental ischemic model. Proceedings of the 7th Annual Meeting of the Society for Treatment of Coma, Vol. 7, pp31-36, 1998

 

54. Nakamura T, Nagao S, Honma Y, Kuyama H: Moderate therapeutic hypothermia for severe head injury - significance of multimodality monitoring. International Perspectives in Traumatic Brain Injury pp59-61, by Australian Academic Press, 1997

 

55. Nagao S, Bemana I, Takahashi E, Nakamura T, Kuyama H. Treatment of acute intracranial hypertension with RU 51599, a selective kappa opioid agonist. Acta Neurochir (Suppl) 70:198-201, 1997

 

56. Bemana I, Takahashi E, Nakamura T, Kuyama H, Nagao S.     OPC-21268, an orally effective, nonpeptide arginine vasopressin V1 receptor antagonist reduces vasogenic brain edema. Acta Neurochir (Suppl) 70:194-197, 1997

 

57. Nakamura T, Miyamoto O, Kawai N, Itano T, Nagao S: The effects of post-ischemic hypothermia on neuronal survival after 1-month in gerbils. Advances in Neurotrauma Research 9, 6-9, 1997

 

58. Bemana I, Takahashi E, Nakamura T, Kuyama H, Nagao S: OPC-21268, a nonpeptide Arginine vasopressin (AVP)V1 receptor antagonist reduces brain edema and protects blood-brain barrier in cold brain injured rats. Advances in Neurotrauma Research 8,12-14, 1996

 

 

和文論文発表

1. 中村丈洋、黒田泰弘:救急・集中治療ガイドライン最新の診療指針:脳神経系疾患の診断・治療・ケア 脳卒中治療室(SCU)の退室指針 再発予知のために:救急・集中治療18, 643-644, 2006

 

2. 中村丈洋、黒田泰弘、板野俊文、長尾省吾:脳内出血の分子病態:分子脳血管病5, 163-167, 2006

 

3. 河井信行、中村丈洋、長尾省吾:脳出血性浮腫の最近の進歩:急性と亜急性:神経進歩50, 249-257, 2006

 

4. 中村丈洋, 山下史朗, 河井信行, 國塩勝三, 長尾省吾, 中野通代, 小倉真治, 宮本修, 板野俊文:低体温療法における導入及び復温時での体温変化による神経細胞への影響についての実験的検討:神経外傷25, 48-52, 2002

 

5. 中村丈洋、國塩勝三、新堂 敦、川西正彦、松本義人、河井信行、小川智也、入江恵子、長尾省吾:蝶形骨洞内の異所性ACTH産生下垂体腺腫の1例:香川脳神経外科談話会会誌16, 39-50, 2002

 

5. 中村丈洋、國塩勝三、三宅啓介、川西正彦、松本義人、河井信行、小川智也、入江恵子、長尾省吾:転移性脳腫瘍と鑑別が困難であった脳内結核腫が疑われた1例:香川脳神経外科談話会会誌16, 11-21, 2002

 

6. 中村丈洋、山下史朗、岡内正信、河井信行、國塩勝三、長尾省吾、宮本 修、板野俊文:実験的頭部外傷後における神経再生の可能性-組織学的および神経行動学的検討-:神経外傷24, 8-12, 2001

 

7. 中村丈洋、宮本 修、山神眞一、岡内正信、河井信行、板野俊文、長尾省吾:実験的脳挫傷モデルにおける低体温およびマンニトールによる抗浮腫効果の検討:脳浮腫・頭蓋内圧研究会報告集3, 15-20, 2001

 

8. 中村丈洋、多田羅尚登、河北賢哉、森崎訓明、長尾省吾:クモ膜下出血後の高度意識障害例における軽度低体温療法中の脳酸素代謝モニタリング:救急・集中治療13, 119-120, 2001

 

9. 中村丈洋、宮本 修、山神眞一、河井信行、板野俊文、長尾省吾:実験的脳挫傷モデルを用いた受傷後急性期における低体温治療効果の検討:脳浮腫・頭蓋内圧研究会報告集2, 53-57, 2000

 

10. 中村丈洋、多田羅尚登、長尾省吾:炎症所見を呈さなかった脳膿瘍の1例:香川脳神経外科談話会会誌14, 1-12, 2000

 

11. 中村丈洋、河井信行、梅岡秀一、岡内正信、入江恵子、國塩勝三、長尾省吾、宮本 修、山神眞一、板野俊文:実験的低体温における連続モニタリングシステム-脳虚血モデルでの検討-:集中治療12, 109-110, 2000

 

12. 中村丈洋, 宮本修, 河井信行, 板野俊文, 長尾省吾:虚血後低体温モデルに対する低濃度MK801長期的投与による神経細胞保護効果:脳循環代謝11, 176-177, 1999

 

13. 中村丈洋、河井信行、小川智也、入江恵子、本間温、長尾省吾、木下順弘、相引眞幸、小栗顕二:重症頭部外傷例に対する軽度低体温療法中のモニタリングからみた頭蓋内病態:神経外傷21, 16-20, 1998

 

14. 中村丈洋、河井信行、入江恵子、本間温、長尾省吾、木下順弘、相引眞幸、小栗顕二:軽度低体温療法中における内頚静脈各種モニタリング-重症頭部外傷例での検討-:集中治療10, 1271-1272, 1998

 

15. 中村丈洋、宮本修、河井信行、林田嘉朗、板野俊文、長尾省吾:酵素電極を用いた微小還流透析法による実験的低体温における復温の影響の検討:脳循環代謝10, 176-182, 1998

 

16. 中村丈洋, 宮本修, 河井信行, 板野俊文, 長尾省吾 :実験的低体温における復温の影響 脳循環代謝からの検討:脳循環代謝10, 78-79, 1998

 

17. 中村丈洋、入江恵子、河井信行、本間 温、久山秀幸、長尾省吾、相引眞幸、小栗顕二:軽度低体温療法中における各種モニタリングの脳循環代謝としての意義-重症頭部外傷例での検討-:集中治療 9, 1359-1360, 1997

 

18. 中村丈洋、本間 温、岩佐綱三、蓮井光一、藤原 敬、久山秀幸、長尾省吾、相引眞幸、小栗顕二:重症頭部外傷患者に対する軽度低体温療法-頭蓋内圧コントロール中の各種モニタリング-:頭蓋内圧研究会報告1996, 57-61, 1996

 

19. 中村丈洋、本間 温、岩佐綱三、蓮井光一、久山秀幸、長尾省吾、相引眞幸、小栗顕二:軽度低体温療法中におけるSjO2モニタリング-重症頭部外傷例での検討-:集中治療8, 1239-1240, 1996

 

20. 中村丈洋、岩佐綱三、入江恵子、新堂敦、斉藤信幸、香川昌弘、藤澤睦夫、本城康正、蓮井光一、笹岡昇、本間温、藤原敬、久山秀幸、長尾省吾、相引眞幸、小栗顕二:重症頭部外傷患者に対する軽度低体温療法の試み:日本神経救急研究会雑誌8, 29-31, 1996

 

 

国際学会発表

1.   Nakamura T, Miyamoto O, Tanaka S, Konishi R, Sumitani K, Tokuda M, Itano T. The protective effects of D-allose on ischemic brain damage in rat. The 3rd Symposium of International Society of Rare Sugaars, November 21-24, 2006, Takamatsu, Japan

 

2.   Nakamura T, Hua Y, Keep RF, Park J, Nagao S, Hoff JT, Xi G. Effects of estrogen on intracerebral hemorrhage-induced brain damage in rats. The XIII International Symposium on Brain Edema and Tissue Injury, Satellite Conference on Intracerebral Hemorrhage, June 4, 2005, Ann Arbor, MI, U.S.A.

 

3.  Nakamura T, Keep RF, Hua Y, Nagao S, Hoff JT, Xi G. Iron-induced oxidative brain injury after experimental intracerebral hemorrhage. The XIII International Symposium on Brain Edema and Tissue Injury, May 31-June 3, 2005, Ann Arbor, MI, U.S.A.

 

4. Nakamura T, Miyamoto O, Yamashita S, Keep RF, Itano T, Nagao S: Delayed precursor cell markers response in hippocampus following cold injury-induced brain edema. The XIII International Symposium on Brain Edema and Tissue Injury, May 31-June 3, 2005, Ann Arbor, MI, U.S.A.

 

5.   Nakamura T, Xi G, Hua Y, Hoff JT, Keep RF. Intracerebral hemorrhage induces edema and oxidative modification and alters NMDA receptor subunits expression. 12th International Symposium of Intracranial Pressure and Brain Monitoring, August 16-20, 2004, Hong Kong

 

6.   Nakamura T, Xi G, Hua Y, Hoff JT, Keep RF. DNA damage in intracerebral hemorrhage: Role of oxidation. International Stroke Conference 2004, February 5-7, 2004, San Diego, CA, U.S.A.

 

7.   Nakamura T, Keep RF, Hua Y, Hoff JT, Xi G. Intracerebral hemorrhage in mice. International Stroke Conference 2004, February 5-7, 2004, San Diego, CA, U.S.A.

 

8.   Nakamura T, Xi G, Hua Y, Hoff JT, Keep RF. Nestin expression after experimental intracerebral hemorrhage. Department of Neurosurgery, University of Michigan. XXIst International Symposium on Cerebral Blood Flow, Metabolism and Function, June 29-July 3, 2003, Calgary, Canada

 

9.  Nakamura T, Kawai N, Yamashita S, Okauchi M, Sumitani K, Miyamoto O, Negi T, Itano T, Nagao S: Effect of hypothermia with cold injury in mice using micro-dialysis monitoring system: 5th International Neurotrauma Symposium, October 1-5, 2000, Garmish-Partenkirchen, Germany

 

10. Nakamura T, Miyamoto O, Kawai N, Okauchi M, Itano T, Nagao S: Therapeutic window of hypothermia after cold-induced injury in mice: International Conference on Recent Advances in Neurotraumatology, November 20-21, 1999, Taipei, Taiwan, R.O.C.

 

11. Nakamura T, Miyamoto O, Kawai N, Itano T, Nagao S: Effect of post-ischemic hypothermia and long-term administration of MK801 on neuronal survival in one month after ischemia: International Stroke Society Regional Meeting at Yokohama, April 22-24, 1999, Yokohama, Japan

 

12. Nakamura T, Miyamoto O, Yamagami S, Okada Y, Negi T, Hatase O, Nagao S, Itano T: The influence of rewarming after hypothermia in gerbil with transient forebrain ischemia: 4th International Neurotrauma Symposium, August 23-28, 1997, Seoul, Korea

 

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