Publications
- "The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin."
Kato K, Iwama H, Yamashita T, Kobayashi K, Fujihara S, Fujimori T, Kamada
H, Kobara H, Masaki T.
Oncol Rep. 2016. 35(3):1582-92.
- "Galectin-9: An anticancer molecule for gallbladder carcinoma."
Tadokoro T, Morishita A, Fujihara S, Iwama H, Niki T, Fujita K, Akashi
E, Mimura S, Oura K, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama
H, Himoto T, Hirashima M, Masaki T.
Int J Oncol. 2016. 48(3):1165-74.
- "Galectin-9 suppresses the proliferation of gastric cancer cells in
vitro."
Takano J, Morishita A, Fujihara S, Iwama H, Kokado F, Fujikawa K, Fujita K, Chiyo T, Tadokoro T, Sakamoto T, Nomura T, Tani J, Miyoshi H, Yoneyama H, Kobara H, Mori H, Niki T, Hirashima M, Masaki T.
Oncology Reports. 2016. 35 (2):851-860
- "Galectin-9 suppresses the growth of hepatocellular carcinoma via apoptosis in vitro and in vivo."
Fujita K, Iwama H, Sakamoto T, Okura R, Kobayashi K, Takano J, Katsura
A, Tatsuta M, Maeda E, Mimura S, Nomura T, Tani J, Miyoshi H, Morishita
A, Yoneyama H, Yamana Y, Himoto T, Okano K, Suzuki Y, Niki T, Hirashima
M, Masaki T.
Int J Oncol. 2015. 46(6):2419-30.
- "Mechanism of gemcitabine-induced suppression of human cholangiocellular
carcinoma cell growth."
Toyota Y, Iwama H, Kato K, Tani J, Katsura A, Miyata M, Fujiwara S, Fujita
K, Sakamoto T, Fujimori T, Okura R, Kobayashi K, Tadokoro T, Mimura S,
Nomura T, Miyoshi H, Morishita A, Kamada H, Yoneyama H, Okano K, Suzuki
Y, Masaki T.
Int J Oncol. 2015. 47(4):1293-302.
- "Galectin-9 suppresses cholangiocarcinoma cell proliferation by inducing
apoptosis but not cell cycle arrest."
Kobayashi K, Morishita A, Iwama H, Fujita K, Okura R, Fujihara S, Yamashita
T, Fujimori T, Kato K, Kamada H, Niki T, Hirashima M, Okano K, Suzuki Y,
Masaki T.
Oncol Rep. 2015. 34(4):1761-70.
- "Antitumor effect of metformin on cholangiocarcinoma: In vitro and in vivo studies."
Fujimori T, Kato K, Fujihara S, Iwama H, Yamashita T, Kobayashi K, Kamada
H, Morishita A, Kobara H, Mori H, Okano K, Suzuki Y, Masaki T.
Oncol Rep. 2015. 34(6):2987-96.
- "MicroRNA profiles following metformin treatment in a mouse model of non-alcoholic steatohepatitis."
Katsura A, Morishita A, Iwama H, Tani J, Sakamoto T, Tatsuta M, Toyota Y, Fujita K, Kato K, Maeda E, Nomura T, Miyoshi H, Yoneyama H, Himoto T, Fujiwara S, Kobara H, Mori H, Niki T, Ono M, Hirashima M, Masaki T.
Int J Mol Med. 2015. 35(4):877-84.
- "Differences in miRNA expression profiles between GIST and leiomyoma
in human samples acquired by submucosal tunneling biopsy."
Fujita K, Kobara H, Mori H, Fujihara S, Chiyo T, Matsunaga T, Nishiyama N, Ayaki M, Yachida T, Morishita A, Fujiwara M, Okano K, Suzuki Y, Iwama H, Masaki T.
Endosc Int Open. 2015 3(6):E665-71.
- "MicroRNA profiles in cisplatin-induced apoptosis of hepatocellular
carcinoma cells."
Miyata M, Morishita A, Sakamoto T, Katsura A, Kato K, Nishioka T, Toyota
Y, Fujita K, Maeda E, Nomura T, Tani J, Miyoshi H, Yoneyama H, Kobara H,
Fujiwara S, Nishiyama N, Iwama H, Himoto T, Hirashima M, Masaki T.
Int J Oncol. 2015. 47(2):535-42.
- "Analysis of the amount of tissue sample necessary for mitotic count and Ki-67 index in gastrointestinal stromal tumor sampling."
Kobara H, Mori H, Rafiq K, Fujihara S, Nishiyama N, Chiyo T, Matsunaga T, Ayaki M, Yachida T, Kato K, Kamada H, Fujita K, Morishita A, Oryu M, Tsutsui K, Iwama H, Kushida Y, Haba R, Masaki T.
Oncol Rep. 2015 33(1):215-22.
- "Profile of microRNAs associated with aging in rat liver."
Mimura S, Iwama H, Kato K, Nomura K, Kobayashi M, Yoneyama H, Miyoshi H,
Tani J, Morishita A, Himoto T, Deguchi A, Nomura T, Sakamoto T, Fujita
K, Maeda E, Izuishi K, Okano K, Suzuki Y, Masaki T.
Int J Mol Med. 2014 34(4):1065-72.
- "Dopamine Receptor Genes and Evolutionary Differentiation in the Domestication
of Fighting Cocks and Long-Crowing Chickens."
Komiyama T, Iwama H, Osada N, Nakamura Y, Kobayashi H, Tateno Y, Gojobori T
PLoS One. 2014 9(7):e101778.
- "Evaluation of gastric submucosal tumors using endoscopically visualized features with submucosal endoscopy."
Kobara H, Mori H, Rafiq K, Matsunaga T, Fujihara S, Nishiyama N, Ayaki
M, Yachida T, Tani J, Miyoshi H, Kato K, Kamada H, Yoneyama H, Morishita
A, Tsutsui K, Iwama H, Haba R, Masaki T.
Oncol Lett. 2014 8(1):161-168.
- "Submucosal tunneling techniques: current perspectives."
Kobara H, Mori H, Rafiq K, Fujihara S, Nishiyama N, Ayaki M, Yachida T, Matsunaga T, Tani J, Miyoshi H, Yoneyama H, Morishita A, Oryu M, Iwama H, Masaki T.
Clin Exp Gastroenterol. 2014 7:67-74.
- "Metformin suppresses expression of the selenoprotein P gene via an
AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes."
Takayama H, Misu H, Iwama H, Chikamoto K, Saito Y, Murao K, Teraguchi A, Lan F, Kikuchi A, Saito R, Tajima N, Shirasaki T, Matsugo S, Miyamoto K, Kaneko S, Takamura T.
J Biol Chem. 2014 289(1):335-45.
- "17ƒÀ-Estradiol regulates scavenger receptor class BI gene expression
via protein kinase C in vascular endothelial cells."
Fukata Y, Yu X, Imachi H, Nishiuchi T, Lyu J, Seo K, Takeuchi A, Iwama
H, Masugata H, Hoshikawa H, Hosomi N, Iwasaki Y, Murao K.
Endocrine. 2014 46(3):644-50
- "Expression profiles of 507 proteins from a biotin label-based antibody
array in human colorectal cancer."
Miyoshi H, Morishita A, Tani J, Sakamoto T, Fujita K, Katsura A, Tatsuta
M, Nomura T, Yoneyama H, Iwama H, Suzuki Y, Masaki T.
Oncol Rep. 2014 31(3):1277-81.
- "Effect of the anti-diabetic drug metformin in hepatocellular carcinoma
in vitro and in vivo."
Miyoshi H, Kato K, Iwama H, Maeda E, Sakamoto T, Fujita K, Toyota Y, Tani
J, Nomura T, Mimura S, Kobayashi M, Morishita A, Kobara H, Mori H, Yoneyama
H, Deguchi A, Himoto T, Kurokohchi K, Okano K, Suzuki Y, Murao K, Masaki
T.
Int J Oncol. 2014 45(1):322-32.
- "Expression of angiogenic factors in hepatocarcinogenesis: Identification by antibody arrays."
Nomura T, Morishita A, Jian G, Mimura S, Kato K, Nomura K, Tani J, Miyoshi
H, Yoneyama H, Sakamoto T, Fujita K, Maeda E, Kobara H, Mori H, Iwama H,
Masaki T.
Oncol Rep. 2013 30(5):2476-80.
- "Human microRNAs originated from two periods at accelerated rates
in mammalian evolution."
Iwama H, Kato K, Imachi H, Murao K, Masaki T.
Mol Biol Evol. 2013 30(3):613-26.
- "Antitumor effect of metformin in esophageal cancer: in vitro study."
Kobayashi M, Kato K, Iwama H, Fujihara S, Nishiyama N, Mimura S, Toyota
Y, Nomura T, Nomura K, Tani J, Miyoshi H, Kobara H, Mori H, Murao K, Masaki
T.
Int J Oncol. 2013 42(2):517-24.
- "Coordinated networks of microRNAs and transcription factors with
evolutionary perspectives."
Iwama H.
Adv Exp Med Biol. 2013 774:169-87.
- "Prediction of protein-destabilizing polymorphisms by manual curation
with protein structure."
Gough CA, Homma K, Yamaguchi-Kabata Y, Shimada MK, Chakraborty R, Fujii
Y, Iwama H, Minoshima S, Sakamoto S, Sato Y, Suzuki Y, Tada-Umezaki M,
Nishikawa K, Imanishi T, Gojobori T.
PLoS One. 2012 7(11):e50445.
- "Prediction of invasion depth for submucosal differentiated gastric
cancer by magnifying endoscopy with narrow-band imaging."
Kobara H, Mori H, Fujihara S, Kobayashi M, Nishiyama N, Nomura T,
Kato K, Ishihara S, Morito T, Mizobuchi K, Iwama H, Masaki T.
Oncol Rep. 2012 28(3):841-7.
- "The antidiabetic drug metformin inhibits gastric cancer cell proliferation in vitro and in vivo."
Kiyohito K, Gong J, Iwama H, Kitanaka A, Tani J, Miyoshi H, Nomura K, Mimura
S, Kobayashi M, Aritomo Y, Kobara H, Mori H, Himoto T, Okano K, Suzuki
Y, Murao K, Masaki T.
Mol Cancer Ther. 2012 11(3):549-60
- "Transcriptional double-autorepression feedforward circuits act for
multicellularity and nervous system development."
Iwama H, Murao K, Imachi H, Ishida T.
BMC Genomics. 2011 12:228.
- gFrequent loss of p19INK4D expression in hepatocellular carcinoma: relationship
to tumor differentiation and patient survival.h
Morishita A, Gong J, Deguchi
A, Tani J, Miyoshi H, Yoshida H, Himoto T, Yoneyama H, Mori H, Kato K,
Kurokohchi K, Deguchi K, Izuishi K, Suzuki Y, Kushida Y, Haba R, Iwama H,
Watanabe S, D'Armiento J, Masaki T.
Oncol Rep. 2011
26(6):1363-8.
- "Exendin-4 regulates the expression of the ATP-binding cassette transporter A1 via transcriptional factor PREB in the pancreatic ƒÀ cell line."
Miyai Y, Murao K, Imachi H, Li J, Nishiuchi Y, Masugata H, Iwama H, Kushida Y, Ishida T, Haba R.
J Endocrinol Invest. 2011 Apr 26. [Epub ahead of print].
- "MicroRNA Networks Alter to Conform to Transcription Factor Networks Adding Redundancy and Reducing the Repertoire of Target Genes for Coordinated Regulation."
Iwama H, Murao K, Imachi H, Ishida T.
Mol Biol Evol. 2011 28(1):639-46.
- "Use of protein array technology to investigate receptor tyrosine kinases activated in hepatocellular carcinoma."
Liu S, Gong J, Morishita A, Nomura T, Miyoshi H, Tani J,Kato K, Yoneyama H, Deguchi A, Mori H, Mimura S, Nomura K, Himoto T, Deguchi K, Okano K, Izuishi K, Suzuki Y, Kushida Y, Haba R, Iwama H, Masaki T.
Exp Ther Med. 2011
2(3):399-403.
- "The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells."
Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Dobashi H, Hosomi N, Masugata H, Zhang GX, Iwama H, Ishida T.
Endocrine. 2010 38(1):53-9.
- "Transcriptional factor prolactin regulatory element-binding protein-mediated
gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate."
Nishiuchi Y, Murao K, Imachi H, Nishiuchi T, Iwama H, Ishida T.
Atherosclerosis. 2010 212(2):418-25.
- "Suppression of prolactin expression by cabergoline requires prolactin
regulatory element-binding protein (PREB) in GH3 cells."
Zhang W, Murao K, Imachi H, Iwama H, Chen K, Fei Z, Zhang X, Ishida T, Tamiya T.
Horm Metab Res. 2010 42(8):557-61.
- "Hyperglycemia suppresses ABCA1 expression in vascular smooth muscle
cells."
Yu X, Murao K, Imachi H, Li J, Nishiuchi T, Hosomi N, Masugata H, Zhang GX, Iwama H, Ishida T.
Horm Metab Res. 2010 42(4):241-6.
- "Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV
pathway."
Li J, Murao K, Imachi H, Masugata H, Iwama H, Tada S, Zhang GX, Kobayashi R, Ishida T, Tokumitsu H.
J Cell Mol Med. 2010 14(5):1083-7.
- "Use of protein array to investigate receptor tyrosine kinases activated
in gastric cancer."
Gong J, Morishita A, Kurokohchi K, Tani J, Kato K, Miyoshi H, Inoue H,
Kobayashi M, Liu S, Murota M, Muramatsu A, Izuishi K, Suzuki Y, Yoshida
H, Uchida N, Deguchi K, Iwama H, Ishimaru I, Masaki T.
Int J Oncol. 2010 36(1):101-6.
- "The prolactin regulatory element-binding regulates of the 11beta-hydroxylase
gene."
Imachi H, Murao K, Cao WM, Muraoka T, Nishiuchi T, Dobashi H, Hosomi N, Iwama H,
Ishida T.
Biochem Biophys Res
Commun. 2008 376(3):531
- "Annexin A2 expression and phosphorylation are up-regulated in hepatocellular carcinoma."
Mohammad HS, Kurokohchi K, Yoneyama H, Tokuda M, Morishita A, Jian G, Shi L,
Murota M, Tani J, Kato K, Miyoshi H, Deguchi A, Himoto T, Usuki H, Wakabayashi
H, Izuishi K, Suzuki Y, Iwama H, Deguchi K, Uchida N, Sabet EA, Arafa UA, Hassan
AT, El-Sayed AA, Masaki T.
Int J
Oncol. 2008 33(6):1157
- "The transcriptional factor prolactin regulatory element-binding protein mediates the gene transcription of adrenal scavenger receptor class B type I via 3',5'-cyclic adenosine 5'-monophosphate."
Murao K, Imachi H, Yu X, Cao WM, Muraoka T, Dobashi H, Hosomi N, Haba R, Iwama
H, Ishida T.
Endocrinology. 2008 ;149(12):6103
- "ReAlignerV: Web-based genomic alignment tool with high specificity
and robustness estimated by species-specific insertion sequences."
Iwama H, Hori Y, Matsumoto K, Murao K, Ishida T.
BMC Bioinformatics. 2008 9(1):112
- "The role of calcium/calmodulin-dependent protein kinase cascade on
MIP-1alpha gene expression of ATL cells."
Matsumoto K, Murao K, Imachi H, Nishiuchi T, Cao W, Yu X, Li J, Ahmed RA,
Iwama H, Kobayashi R, Tokumitsu H, Ishida T.
Exp Hematol. 2008
- "Evola: Ortholog database of all human genes in H-InvDB with manual
curation of phylogenetic trees."
Matsuya A, Sakate R, Kawahara Y, Koyanagi KO, Sato Y, Fujii Y, Yamasaki
C, Habara T, Nakaoka H, Todokoro F, Yamaguchi K, Endo T, Oota S, Makalowski
W, Ikeo K, Suzuki Y, Hanada K, Hashimoto K, Hirai M, Iwama H, Saitou N,
Hiraki AT, Jin L, Kaneko Y, Kanno M, Murakami K, Noda AO, Saichi N, Sanbonmatsu
R, Suzuki M, Takeda J, Tanaka M, Gojobori T, Imanishi T, Itoh T.
Nucleic Acids Res. 2008 36(Database issue):D787-92
- "Abundance of microRNA target motifs in the 3'-UTRs of 20527 human
genes."
Iwama H, Masaki T, Kuriyama S.
FEBS Lett. 2007 581(9):1805-10.
- "Identification of c-Yes expression in the nuclei of hepatocellular
carcinoma cells: Involvement in the early stages of hepatocarcinogenesis."
Nonomura T, Masaki T, Morishita A, Jian G, Uchida N, Himoto T, Izuishi
K, Iwama H, Yoshiji H, Watanabe S, Kurokohchi K, Kuriyama S.
Int J Oncol. 2007 30:105-11
- "Activation of c-Yes in hepatocellular carcinoma: a preliminary study"
Feng H, Masaki T, Nonomura T, Morishita A, Jian G, Nakai S, Deguchi A,
Uchida N, Himoto T, Iwama H, Usuki H, Wakabayashi H, Izuishi K, Yoshiji
H, Kurokohchi K, Kuriyama S.
World J Gastroenterol. 2006 12:5743-5.
- "Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation"
Ohtsuka S, Murao K, Imachi H, Cao WM, Yu X, Li J, Iwama H, Wong NC, Bancroft
C, Ishida T.
Diabetologia. 2006 49:1599-607
- "The map-based sequence of the rice genome"
International Rice Genome Sequencing Project.
Matsumoto, T. et al. ---------- (Area of Physical Maps and Sequencing)
Iwama, H., Gojoboti T. et al. ---- (Area of Annotation and Analysis)
Benjamin, B. ---------------- (Coordination)
Nature 2005 436:793-800
- gStructural and Functional Analysis of a 0.5-Mb Chicken Region Orthologous to
the Imprinted Mammalian Ascl2/Mash2-Igf2-H19 Region.h
Yokomine, T, Shirohzu, H, Purbowasito, W, Toyoda, A, Iwama, H, Ikeo, K,
Hori, T, Mizuno, S, Tsudzuki, M, Matsuda, Y, Hattori, M, Sasaki, Y and
Sasaki, H.
Genome Res. 2005, 15:154-65
- gHighly Conserved Upstream Sequences for Transcription Factor Genes and
Implications for the Regulatory Networkh
Iwama, H. and Gojobori, T
Proc. Natl. Acad. Sci. U. S. A. 2004, 101:17156-61
==== Top-9
Most-Frequently-Read Article in PNAS during
Dec. 2004. ====
- gThe Genome Sequence and
Structure of Rice Chromosome 1h
Sasaki T, Matsumoto T, Yamamoto K, Sakata K, Baba T, Katayose Y, Wu J,
Niimura Y, Cheng Z, Nagamura Y, Antonio BA, Kanamori H, Hosokawa S, Masukawa
M, Arikawa K, Chiden Y, Hayashi M, Okamoto M, Ando T, Aoki H, Arita K,
Hamada M, Harada C, Hijishita S, Honda M, Ichikawa Y, Idonuma A, Iijima
M, Ikeda M, Ikeno M, Ito S, Ito T, Ito Y, Ito Y, Iwabuchi A, Kamiya K,
Karasawa W, Katagiri S, Kikuta A, Kobayashi N, Kono I, Machita K, Maehara
T, Mizuno H, Mizubayashi T, Mukai Y, Nagasaki H, Nakashima M, Nakama Y,
Nakamichi Y, Nakamura M, Namiki N, Negishi M, Ohta I, Ono N, Saji S, Sakai
K, Shibata M, Shimokawa T, Shomura A, Song J, Takazaki Y, Terasawa K, Tsuji
K, Waki K, Yamagata H, Yamane H, Yoshiki S, Yoshihara R, Yukawa K, Zhong
H, Iwama H, Endo T, Ito H, Hahn JH, Kim HI, Eun MY, Yano M, Jiang J, Gojobori
T.
Nature 2002, 420:312-316
- gIdentification of Neurotransmitter Receptor Genes
under Significantly Relaxed Selective Constraint by Orthologous Gene Comparisons
between Humans
and
Rodentsh
Iwama, H. and Gojobori, T.
Mol. Biol. Evol. 2002, 19:1891-1901
- gEvolution of molecules involved with
neural transmission: in the case of catecholamine receptors and G protein
alpha subunitsh
Iwama, H. and Gojobori, T.
Tanpakushitsu Kakusan Koso. 2001, 46(11 Suppl):1586-93. Review. in
Japanese
- gEpstein-Barr Virus Detection in Kidney
Biopsy Specimens Correlates with Glomerular Mesangial Injuryh
Iwama, H., Horikoshi, S., Shirato, I. and Tomino, Y.
Am. J. Kidney Dis. 1998, 32:785-793