The programs in lintrdos.zip are for (1) testing the molecular clock on a given topology of a phylogenetic tree and (2) making linearized trees (reestimating branch lengths under the assumption of constant rate of evolutions. The data that can be used are nucleotide or amino acid sequences. For details of the methods, please look at "Phylogenetic tests of the molecular clock and linearized trees" (Molecular Biology and Evolution 12: 823-833, 1995). (1) Download lintrdos.zip and lintrdos.readme onto your system in the binary mode. (2) Uncompress lintrdos.zip (3) Read the readme.txt file first. The programs are compiled for MSDOS. If you have problems or comments, please send email to: takezaki@med.kagawa-u.ac.jp Naoko Takezaki Life Science Research Center Kagawa University TEL/FAX +81-87-891-2419 Email : takezaki@med.kagawa-u.ac.jp