The programs in lintre.unix.tar.Z are for (1) testing the molecular clock on a given topology of a phylogenetic tree and (2) making linearized trees (reestimating branch lengths under the assumption of constant rate of evolutions. The data that can be used are nucleotide or amino acid sequences. For details of the methods, please look at "Phylogenetic tests of the molecular clock and linearized trees" (Molecular Biology and Evolution 12: 823-833, 1995). (1) Download lintre.unix.tar.gz and lintre.unix.readme onto your system in the binary mode. (2) Type "tar zxvf lintre.unix.tar.gz". (3) Read the readme file first. If you have problems or comments, please send email to: takezaki@med.kagawa-u.ac.jp April 7, 2010 Naoko Takezaki Life Science Research Center Kagawa University TEL/FAX +81-87-891-2419 Email : takezaki@med.kagawa-u.ac.jp