Carcinoma of the colon in childhood: Report of 2 cases
expressing p53 without K-ras mutation
Akira Toki, Takuji Todani, Yasuhiro Watanabe, Kaoru Ogura, Akimistu Miyauchi,
Yoshiko Agatsuma
Eur J Pediatr Surg 7: 315-317, 1997
We report on 2 children with colonic carcinoma and also review 62 cases
of Japanese children with colonic carcinoma including ours. Although the
dismal prognosis in colonic cancer in children is possibly due to the predominance
of poorly differentiated carcinoma, there is no significant difference in
the 5-year survival rates among well, moderately and poorly differentiated
carcinomas in children. Positive staining with p53 in tumor cells was observed
in each, but K-ras mutations were not detected in any. Therefore, these
carcinomas possibly developed from de-novo carcinoma. The development pathway
of colonic carcinoma may relate to the prognosis in children, and be different
from that in adults.
Return