Effects of Enteral Fat Emulsion on Fat Absorption in Obstructive
Jaundiced Rats
Yasuhisa Sato, Takuji Todani, Akira Toki, Yasuhiro Watanabe, Sadashige Uemura,
Yoshiki Morotomi
J Parenter Enteral Nutr 15: 408-411, 1991
The effects of fat emulsion given enterally on fat absorption
were studied with obstructive jaundiced rats (J group) as compared with
jaundice-free rats (C group). The J and C groups were subdivided into JE
and CE groups using emulsified fat for the fat absorption test, and JU and
CU groups using unemulsified fat. Rats in all groups were fed for 7 days
with regular rat chow. After fasting for 12 hours, 14C-labeled fat emulsion
was infused to the JE and CE, and 14C-labeled unemulsified fat to the JU
and CU groups through a gastrostomy for the absorption test. The hourly
and cumulative output of 14C02 by respiration, absorption rate of 14C-labeled
fat in the intestine, and metabolic oxidation rate of the absorbed fat were
determined during an 8-hour period after the gastroenteral administration
of emulsified or unemulsified fat. The peak of hourly output was seen after
the first 2 hours in the CE, JE, and CU groups, following which a remarkable
decline was seen in the CE and CU groups. However, a more gentle descent
in the JE, and fluctuation at a low level in the JU group were observed.
The cumulative output in the JE was 61% of that in the CE, while the output
in the JU was 16% of that in the CU group. The absorption rate in the JE
was 81% of that in the CE group, while the rate in the JU was 22% of that
in the Cu group. These results show that the emulsified fat is more readily
absorbed from the intestine even in jaundiced rats than the unemulsified
fat and suggest that a fat module composed of fine emulsified fat may be
effective in patients with insufficient excretion of bile acid.
Return