Effects of Pectin and Cellulose on Fat Absorption After
Massive Small-Bowel Resection in Weaning Rats
Akira Toki, Takuji Todani, Yasuhiro Watanabe, Sadashige Uemura, Yasuhisa
Sato, Yoshiki Morotomi
J Parenter Enteral Nutr 16: 255-258, 1992
The effects of pectin and cellulose on fat absorption
after massive small-bowel resection were studied in rats. Weaning Wistar
rats underwent 80% resection of the small intestine with gastrostomy, and
fat emulsion labeled with 14C-linoleate was given via a gastrostomy tube
for the fat absorption test on the 10th postoperative day. They were classified
into three groups by diet as follows: E group, a fiber-free, chemically
defined diet (CDD); EP group, CDD with 2% pectin; and EC group, CDD with
2% cellulose. The cumulative and hourly output of 14C in the expired air,
the absorption rate of 14C in the intestine, and the metabolic utilization
rate of 14C were calculated. The cumulative 14C02 output was significantly
lower in the EC group than in the E and EP groups. However, there was no
significant difference in the 14C02 Output between the E and EP groups.
The highest hourly 14C02 Output in the E and EP groups was observed during
the first 2 hours. However, in the EC group, this fluctuated at low levels.
No significant difference in the 1-14C-linoleate absorption rate was observed
between the E and EP groups, whereas it was significantly lower in the EC
group than in the E and EP groups. The metabolic utilization rate of 1-14C-linoleate
showed no significant difference among the three groups. These data suggest
that an addition of pectin to CDD does not impair small intestinal absorption
of 1-14C-linoleate after massive small-bowel resection, and an addition
of cellulose decreases absorption of 1-14C-linoleate.
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