The effects of feeding and secretin administration on the
pancreaticoduodenal papilla of conscious dogs
Yoshiki Morotomi, Takuji Todani, Hiroshi Hosomi
Surgery Today 24: 707-712, 1994
The aim of this study was to define the functional role
of the pancreaticoduodenal papilla (PDP) in the regulation of pancreatic
outflow into the duodenum in response to feeding and secretin administration
in conscious dogs. The canine model we developed allowed for measurement
of the pancreatic ductal pressure and pancreatic outflow simultaneously
in a physiological state without interfering with the flow of pancreatic
juice via the intact sphincter of the duodenal papilla. Feeding increased
the pancreatic outflow from 2.8+-0.2 to 13.4+-1.3ml/15 min with a slight
increase in the pancreatic ductal pressure from 8.5+-0.6 to 13.7+-1.4 cmH20.
The administration of secretin increased the pancreatic outflow from 2.8+-0.2
to 12.7+-1.0ml/15 min without increasing the pancreatic ductal pressure.
The viscosity of the pancreatic juice increased during exposure to food,
but decreased following food intake and secretin administration, after which
the PDP seemed to dilate by about 40% of the fasting value. The results
suggest that PDP changes its opening to maintain the pancreatic ductal pressure
below a certain level, even if pancreatic secretion into the pancreatic
duct increases due to food intake and secretin administration.
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