Bone mineral analysis in patients with biliary atresia
after successful Kasai procedur
Akira Toki, Takuji Todani, Yasuhiro Watanabe, Yasuhisa Sato, Kaoru Ogura,
Mikiko Yoshikawa, Sae Yamamoto, Zhong-Qiu Wang
Tohoku J Exp Med 181, 213-216, 1997
Metabolism is probably disturbed in patients with abnormal
liver function who have undergone a successful Kasai procedure. We examined
bone mineral metabolism in patients who have successfully undergone Kasai
procedure. Bone mineral metabolism was examined in 8 patients with biliary
atresia after a successful Kasai procedure. Five patients were female and
3 were male. The es at Kasai procedure ranged from 50 to 80 days, and the
follow-up periods ranged from 3 to 27 years after the operation. All patients
eat a normal oral diet. We examined plasma levels of 25-0H-D3, 1, 25-(OH)2-D3,
Ca and phosphorus (P). Bone mineral content of the lumbar spine (L2-L4)
was assessed by dual energy x-ray absorptiometry (DEXA), and the data were
expressed as a bone mineral density (BMD). Two patients showed abnormal
levels on hepatic function tests. Plasma levels of 1, 25-(OH)2-D3, Ca, and
P were normal in all patients. The level of 25-0H-D3 was normal in 7 patients.
BMD Ievels were normal in 6 patients, but low in 2 who had undergone partial
splenic embolization and splenectomy, respectively, due to hypersplenism.
In long-term survivors of Kasai procedure, measurement of BMD may detect
bone mineral deficiency earlier than measurements of serum levels of 25-0H-D,
1, 25-(OH)2-D, Ca and P.
Return