Carcinoma Arising in the Wall of Congenital Bile Duct Cysts
Takuji Tondani, Katsusuke Tabuchi, Yasuhiro Watanabe, Toshiyuki Kobayashi
Cancer 44:1134- 1141, 1979
The incidence of carcinoma arising in the wall of the
congenital bile duct cysts is much higher than previously assumed. The authors
report 4 such cases of primary and secondary carcinomas and review their
clinical features through the similar 59 cases in the literature. Of the
63 cases, the average age was much younger, at least several decades, compared
with cases of extrahepatic carcinoma without bile duct cysts. The female-male
ratio was 2.5:1. Racial preponderance was also observed, namely, the majority
were Japanese. Additionally, many patients previously received various internal
drainage procedures, especially choledochocystoduodenostomy. As the treatment,
primary excision of the extrahepatic bile duct cyst seems to give the best
results because it can avoid ascending cholangitis and prevent development
of carcinoma. However, carcinoma still can arise in the intrahepatic bile
duct cyst, which cannot be removed at the present time.
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